Well, we started with physical health, moved on to mental health... And by page six, we have saturated the thread with drug use. I went through my mind opening phase of life once I was on my own, starting with 18 but truly taking off in my 20's. I experimented a lot, have tried pretty much anything at least once.
They can all be fun, if not beneficial used in moderation. Now days, you can't know if it's pure, or laced with something deadly. Kinda takes the fun, and benefit away if it could kill you.
You can grow your own weed, not as strong as the pot shop weed. Alcohol is pretty safe because it's legal and regulated. Can't make your own coke, so that's a risky crapshoot. Same with heroin. Meth is just gross on many levels.
I've never been into pharmaceuticals for recreation, they just make me fall asleep anyway. Which is why I took them (prescribed)... To sleep because I'm in pain from an injury, resting, so it can heal.
ETA, shrooms & acid... Each can lead to a bad trip. Experienced good and bad with LSD, never bad with shrooms. "Don't panic when it's organic."