I handle RIPs, integrations, JDF automations, and digital processing automations for several companies. I have spent countless hours in front of every RIP on the market. Some 2 cent opinions based on my experience.
- If you need something cost effective, reliable, easy to use, and user-friendly semi-advanced options - Onyx Thrive. Keep the subscription, it's invaluable. Profiling is designed to be effective for less advanced users. Very good online documentation. This is good for the vast majority of shops.
- Flexi is fine when it's comes in as a package and you just need simple printing. Not for your use though.
- GMG Print Factory is the most advanced and robust system. You get every feature you can imagine, cloud analytics, multiple print engines, client/server commercial design, etc. Their pricing is very simple and straight-forward. Some licenses need to occasionally be purchased or upgraded. Again, keep their maintenance contract, it's invaluable. A bonus here is that GMG Color Proof is a big market segment in ad agencies and large printers. Combining the two is obviously beneficial, and running the same rip as lots of ad agencies is obviously beneficial. This is not the cheapest option by any means, but it is by far the most feature rich and robust.
- Caldera is a legacy standard in the market. I have moved every shop I handle off of them and no one has looked back. It is very robust and color accurate. Lots of features, but they omit lots of other features that are included in all competitor's packages (you can buy these features at an exorbitant extra price). Their pricing model has not changed as the market got more competitive, so you will end up paying a lot more here over time as they nickel and dime you to death. They will be stuck on Mac and Linux forever as they are unable to fundamentally rewrite or update the software since it's core was released in 1998. Investing here has increasingly been a diminishing return. Advanced tasks like auto-rip workflows and JDF are a nightmare. Operators make lots of mistakes and waste due to it's user-unfriendly design multiplied by lack of automations. Poor online documentation for new users. I would also note that their support is extremely slow and difficult to deal with. Shop down? They'll get to you in 1-2 days.
There are a handful of other options, but the most common solution for most shops is either Onyx or Caldera at the moment. Do some demos or trials, choose what's best for you, print.