Not sure if I've had that issue, but to be honest not sure if I've checked panels to be within 1/4'' because I rarely print my drops at the same width.
I have had a coalescence issue with DS Matte though. On multiple roles. It isn't a substrate advance, or an optimizer issue (unless I just can't seem to dial in the right setting). The problem is, every single other media prints fine, but DS Matte always comes out with a sporadic grain, and just doesn't coalesce in the dark tones.
The Matte seems to be *really* prone to curling though, seems like I have to cut a new fresh piece every time I load it.
Off the top of my head I would temperature, or curing time could be an issue with your problem. What profile are you using?