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assuming you have a roll to roll HP instead of a flatbed
Also assuming you do not have white ink
print to a frosted material (reverse image), make sure to you use heavy ink coverage(many passes)
install onto the 2nd side (backside) of clear acrylic, this will show the correct orientation when viewed on the front side
mount using standoffs,
would suggest drilling the holes BEFORE applying the vinyl.
NOTE: regardless of the bit you use, MAKE SURE you start with a small bit and increase one size at a time until you have the desired diam.
also, make sure to use tape on the front/back of the acrylic where you are drilling