We use 3850 exclusively for our back-lit
signs. Double strike on our Epson.
If your not using a vinyl that can stand up to the heat of a light box, and the environment... you'll get cracking. If you do use a clear vinyl, you should probably be doing color-white-color, but at that point I'd just use the Translucent vinyl and save on the white ink.
Don't try to use a regular non translucent calendered vinyl and light that up, we tried with a few different ones for giggles and they were blotchy and fuzzy when lit up. They looked terrible.