Striping is a not a good idea. If you have ever paid for data recovery you'll know why. You double your probability of a total loss. A RAID 5 2+1 setup gives you some performance increases along with fault protection. Furthermore, unless the RAID card utilizes the PCI-E or a PCI-X bus, you're going to hit a nasty bottle neck.
Also, a quad core for a design station is silly. More clock on a dual core is better suited to that application. Also, no flavor of
Windows is particaularly good with SMP, and Adobe stuff is notoriously bad. Unless you're Johnny multi-task, its not the best fit. Also, be leary of anything that has "1" slot available. This means the memory isn't double pumping. While bench marks have shown that dual channel doesn't really give the as advertised performance increase, not running matched pairs of ram is a handicap nonetheless.