Option 1: To block out what you want opaque print a solid black shape over the block-out area like below, then load and print color/ white/ color like you would any backlit to keep the colors from washing out that will be lit. As long as you just load layers from the same file and don't move the substrate on the printer, the separate prints will line up perfectly. Used to do stuff like this all the time, some I had to go over 4-5 times with different files. This will make the face look like a regular print, and when lit it won't allow light through where you don't because of the solid black. When you do the black you can double hit it if you think you need to make it more opaque. Grab some scrap and experiment.
Option 2: More difficult because you have to make sure it's lined up as close as possible. Do color/ white/ color on the face, flip the
sign face and print black reversed on the back side.
Option 3: Print the front color/ white/ color, then cut your block-out shape reversed from black
sign vinyl, align it, and lay it on the back side.
Either way it will show the full image on the top, and only allow light through where you want it. If you were working with translucent vinyl you'd print the face as normal, do a reverse print on clear over the back side, and cover the block-out area from the back with black
sign vinyl for the full block-out where you want it.
Make sense???