If it's a commodity you're selling (like stickers). It's tough to compete with everyone else online. It's easier and you can charge a higher amount to people that don't want to buy online. Expand your area from your small town to other small towns in your region and get their local business. Local large companies may not be able to buy online cause they need POs. Those would be good to go after. Local doesn't always mean your town only... Think regionally.
Not a bad idea, and worth exploring, but may not yield the expected results.
I have worked with most of the large companies in my area (mostly on custom, specialized products that will be used for commemorations and trade show use where the volume is small, often just one piece). Even though I had good relations, trying to crack the high volume market was mostly unsuccessful (the big production shops that can handle large volumes, packaging, and logistics are better equipped and staffed to handle those demands at a much more competitive price).
Most of these companies will issue credit cards to department heads so that they can make small, discretionary purchases without going through the purchasing department (P.O.s not needed), usually under a couple thousand dollars (I will admit that I sometimes conspired with buyers and issued several invoices to be under the maximum discretionary threshold for single purchases, usually with the tacit approval from the purchasing department because they did not want to be burdened by the hassle of small purchases and who knew and trusted the department heads). Most of these discretionary purchases are for things like office supplies, items to be used internally by the department, meals, transportation costs, hotels, etc. People love stickers, and you may get some traction there, especially if you already have relations with the companies.