We have two Roland printers with TR-2 ink, and not only do we run the cartridges all the way down, but when the machine says it's empty, I'll remove the cartridge, and use a squeegee to combine and push all the ink towards the edge, and pop it back in the machine.Sometimes we get a full day of printing before it beeps again and needs to be swapped out for a new one. I haven't clocked any loss or quality of color doing this... I feel like we've saved a lot of money this way, ink being more expensive than it ever was. If there's a large job in progress, and a printer operator is leaving for the day or taking lunch, they'll swap out any of the almost empty cartridiges for new ones, so it doesn't stop the print when no one is present. When they come back they swap the old one back in and use them until they're empty. One time when the majority of the cartridges were all super low at the same time we saw some color inconsistency, but that was a one off.