It all depends on how much you're printing.
If you're going to print 50
signs on reflective.... I wouldn't do it on UV. We used to screen print 1000s of realtor
signs, then just imprint the names - on our fb500 whenever we did it to reflective, the nozzles would start dropping.... They always came back with a cleaning, but we were printing 6" areas, I can't imagine printing tons of full
signs and it not clogging the head.
What printer is it?
If you're truely worried and have a flatbed.... Most flatbeds can print with the UV lights off, then you can cap / cover the Printhead and then run a pass with just UV lights. Obviously you're taking twice as long to print this way... But at least you're not risking ruining a head. Good if you have long lengths of UV printing to do.
Of course it all depends too. On our q500 the UV lights are a good 10-12" away from the heads, and it prints a few cm above the media... There's no way for the light to get to the heads even on a mirrored surface. So it's pretty much case by case.
As for the actual print - our fb500 was opaque and it took away from the reflective was. Our q500 ink gives it a metallic look... It's unique, but you do lose some reflectivity.