Hi Colin. I have used Signlab, Anagraph's Designart2000, Corel ver. 9 with sign tools3.
I started with anagraph 3.5,went to designart 2000, had a lot of problems with the software, and decided to try corel with signtools. I haven't mastered corel, but it works well with the signtools, and signtools support has always helped when there was a problem. I have also heard good things about co-cut. I prefer signlab, probably the software I have spent the most time on, but have been happy with corel, as it does some things easier than in signlab. I feel I can't go wrong with both, and Corel is ALOT cheaper, along with signtools.
George