Hand drawn? WHAAAAAT? Just kidding. IMHO to attain top quality outputs from images drawn by human hand, there will exist a
computer operator who vectors it in Illustrator® from a scanned image. Streamline! Nostagia! It worked when Corel 8 CorelTrace DID NOT!
Hand drawn on acetate with Sharpie® or Staedtler® Lumocolor at large scale [at least 1:4 - maximum 4x enlargement when cut] can work if art is vectorized in CorelTrace X4 or X5 and nodes manually edited. Acetate avoids bleed that vellum or
paper causes due to ink bleeding in the fibers.
A quality graphic artist will be adept at editing nodes in their chosen vector based software: Illustrator, Corel, SignLab, Flexi, VMP ...et. al.
A crap cut from vector in vinyl is a outward
sign of a crappy graphic artist: patience, skill and such. (trademarks property of their respective owners).